The Highly Efficient 1,4-Addition of TMSCN to Aromatic Enones Catalyzed by CsF with Water as the Additive
Jingya Yang, Yinxian Wang, Shaoxiang Wu, Fu-Xue Chen*
*Department of Applied Chemistry, School of Chemical Engineering & the Environment, Beijing Institute of Technology, No. 5 South Zhongguancun Street, Haidian District, Beijing 100081, P. R. of China, Email: fuxue.chenbit.edu.cn
J. Yang, Y. Wang, S. Wu, F.-X. Chen, Synlett, 2009, 3365-3367.
DOI: 10.1055/s-0029-1218376 (free Supporting Information)
see article for more reactions
An efficient 1,4-addition of TMSCN to aromatic enones has been achieved in excellent yields in the presence of CsF as catalyst and H2O as an additive in refluxing dioxane.
see article for more examples
J. Yang, Y. Shen, F.-X. Chen, Synthesis, 2010, 1325-1333.
1,4-addition reaction, enones, nitriles, regioselectivity, CsF