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A Mild and Inexpensive Procedure for the Synthesis of N,N'-Di-Boc-Protected Guanidines

Andrea Porcheddu*, Lidia De Luca, Giampaolo Giacomelli

*Dipartimento di Chimica, UniversitÓ degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy, Email:

A. Porcheddu, L. De Luca, G. Giacomelli, Synlett, 2009, 3368-3372.

DOI: 10.1055/s-0029-1218365


The use of cyanuric chloride (TCT) instead of classical HgCl2 as activating reagent for di-Boc-thiourea provides an alternative route for the guanylation of amines and eliminates the environmental hazard of heavy-metal waste without appreciable loss of yield or reactivity.

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Key Words

cyanuric chloride, TCT, guanidines, N,N'-di-Boc-protected guanidines, guanylating reagent

ID: J60-Y2009-3690