A Mild and Inexpensive Procedure for the Synthesis of N,N'-Di-Boc-Protected Guanidines
Andrea Porcheddu*, Lidia De Luca, Giampaolo Giacomelli
*Dipartimento di Chimica, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy, Email: anpouniss.it
A. Porcheddu, L. De Luca, G. Giacomelli, Synlett, 2009, 3368-3372.
DOI: 10.1055/s-0029-1218365
Abstract
The use of cyanuric chloride (TCT) instead of classical HgCl2 as activating reagent for di-Boc-thiourea provides an alternative route for the guanylation of amines and eliminates the environmental hazard of heavy-metal waste without appreciable loss of yield or reactivity.
see article for more examples
Key Words
cyanuric chloride, TCT, guanidines, N,N'-di-Boc-protected guanidines, guanylating reagent
ID: J60-Y2009-3690