Organozinc Generation via the Titanium-Catalyzed Activation of Alkyl Halides
Lauren M. Fleury and Brandon L. Ashfeld*
*Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, Email: bashfeldnd.edu
L. M. Fleury, B. L. Ashfeld, Org. Lett., 2009, 11, 5670-5673.
DOI: 10.1021/ol902374v (free Supporting Information)
Titanocene dichloride catalyzes the formation of an organozinc species via catalytic activation of allyl halides. Nucleophilic addition to carbonyl derivatives provides the desired homoallylic alcohols in very good yields in short reaction times. This discovery will have wide ranging applicability in the generation of highly reactive organometallic reagents.
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