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Propylphosphonic Anhydride (T3P): A Remarkably Efficient Reagent for the One-Pot Transformation of Aromatic, Heteroaromatic, and Aliphatic Aldehydes to Nitriles

John Kallikat Augustine*, Rajendra Nath Atta, Balakrishna Kolathur Ramappa, Chandrakantha Boodappa

*Syngene International Ltd., Biocon Park, Plot Nos. 2 & 3, Bommasandra IV Phase, Jigani Link Road, Bangalore 560 099, India, Email: john.kallikatsyngeneintl.com

J. K. Augustine, R. N. Atta, B. K. Ramappa, C. Boodappa, Synlett, 2009, 3378-3382.

DOI: 10.1055/s-0029-1218388 (free Supporting Information)


Abstract

Propylphosphonic anhydride (T3P) is an efficient reagent for the transformation of aromatic, heteroaromatic, and aliphatic aldehydes to respective nitriles in excellent yields. This procedure offers simple and one-pot access to nitriles and highlights the synthetic utility of T3P as a versatile reagent in organic chemistry.

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Key Words

propylphosphonic anhydride, dehydration, nitriles, aldoximes, electrophilic activation


ID: J60-Y2009-3730