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Propylphosphonic Anhydride (T3P): A Remarkably Efficient Reagent for the One-Pot Transformation of Aromatic, Heteroaromatic, and Aliphatic Aldehydes to Nitriles

John Kallikat Augustine*, Rajendra Nath Atta, Balakrishna Kolathur Ramappa, Chandrakantha Boodappa

*Syngene International Ltd., Biocon Park, Plot Nos. 2 & 3, Bommasandra IV Phase, Jigani Link Road, Bangalore 560 099, India, Email:

J. K. Augustine, R. N. Atta, B. K. Ramappa, C. Boodappa, Synlett, 2009, 3378-3382.

DOI: 10.1055/s-0029-1218388


Propylphosphonic anhydride (T3P) is an efficient reagent for the transformation of aromatic, heteroaromatic, and aliphatic aldehydes to respective nitriles in excellent yields. This procedure offers simple and one-pot access to nitriles and highlights the synthetic utility of T3P as a versatile reagent in organic chemistry.

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Key Words

propylphosphonic anhydride, dehydration, nitriles, aldoximes, electrophilic activation

ID: J60-Y2009-3730