Propylphosphonic Anhydride (T3P): A Remarkably Efficient Reagent for the One-Pot Transformation of Aromatic, Heteroaromatic, and Aliphatic Aldehydes to Nitriles
John Kallikat Augustine*, Rajendra Nath Atta, Balakrishna Kolathur Ramappa, Chandrakantha Boodappa
*Syngene International Ltd., Biocon Park, Plot Nos. 2 & 3, Bommasandra IV Phase, Jigani Link Road, Bangalore 560 099, India, Email: john.kallikatsyngeneintl.com
J. K. Augustine, R. N. Atta, B. K. Ramappa, C. Boodappa, Synlett, 2009, 3378-3382.
Propylphosphonic anhydride (T3P) is an efficient reagent for the transformation of aromatic, heteroaromatic, and aliphatic aldehydes to respective nitriles in excellent yields. This procedure offers simple and one-pot access to nitriles and highlights the synthetic utility of T3P as a versatile reagent in organic chemistry.
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propylphosphonic anhydride, dehydration, nitriles, aldoximes, electrophilic activation