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Silver-Catalyzed Protodecarboxylation of Heteroaromatic Carboxylic Acids

Pengfei Lu, Carolina Sanchez, Josep Cornella and Igor Larrosa*

*School of Biological and Chemical Sciences, Queen Mary University of London, Joseph Priestley Building, Mile End Road, E1 4NS London, U.K., Email:

P. Lu, C. Sanchez, J. Cornella, I. Larrosa, Org. Lett., 2009, 11, 5710-5713.

DOI: 10.1021/ol902482p


A simple and highly efficient protodecarboxylation of various heteroaromatic carboxylic acids is catalyzed by Ag2CO3 and AcOH in DMSO. This methodology enables also a selective monoprotodecarboxylation of several aromatic dicarboxylic acids.

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Key Words

decarboxylations, furans, benzofurans, thiophenes, pyridines

ID: J54-Y2009-3740