Dioxygen Activation under Ambient Conditions: Cu-Catalyzed Oxidative Amidation-Diketonization of Terminal Alkynes Leading to α-Ketoamides
Chun Zhang and Ning Jiao*
*State Key Laboratory of Natural and Biomimetic Drugs, School
of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191,
China, Email: jiaoningbjmu.edu.cn
C. Zhang, N. Jiao, J. Am. Chem. Soc., 2010, 132, 28-29.
DOI: 10.1021/ja908911n
Abstract
A Cu-catalyzed oxidative amidation-diketonization reaction of terminal alkynes leads to α-ketoamides. In this copper-catalyzed radical process, O2 not only participates as the ideal oxidant but also undergoes dioxygen activation under ambient conditions.
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proposed mechanism
C. Zhang, X. Zong, L. Zhang, N. Jiao, Org. Lett., 2012, 14, 3280-3283.
Key Words
Diketonization, Oxidative Amidation, Oxygen, TEMPO
ID: J48-Y2010-0040