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Efficient Copper-Catalyzed Synthesis of 4-Aminoquinazoline and 2,4-Diaminoquinazoline Derivatives

Xiaobo Yang, Hongxia Liu, Hua Fu*, Renzhong Qiao, Yuyang Jiang, Yufen Zhao

*Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. of China, Email:

X. Yang, H. Liu, R. Qiao, Y. Jiang, Y. Zhao, Synlett, 2010, 101-106.

DOI: 10.1055/s-0029-1218530 (free Supporting Information)


An efficient copper-catalyzed reaction of substituted 2-bromo-benzonitriles with amidines or guanidine allows an economical and practical synthesis of 4-aminoquinazoline and 2,4-diaminoquinazoline derivatives.

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Key Words

copper, Ullmann-type reaction, cross-coupling, quinazolines, synthetic method

ID: J60-Y2010-0050