Efficient Copper-Catalyzed Synthesis of 4-Aminoquinazoline and 2,4-Diaminoquinazoline Derivatives
Xiaobo Yang, Hongxia Liu, Hua Fu*, Renzhong Qiao, Yuyang Jiang, Yufen Zhao
*Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. of China, Email: fuhuamail.tsinghua.edu.cn
X. Yang, H. Liu, R. Qiao, Y. Jiang, Y. Zhao, Synlett, 2010, 101-106.
DOI: 10.1055/s-0029-1218530
Abstract
An efficient copper-catalyzed reaction of substituted 2-bromo-benzonitriles with amidines or guanidine allows an economical and practical synthesis of 4-aminoquinazoline and 2,4-diaminoquinazoline derivatives.
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Key Words
copper, Ullmann-type reaction, cross-coupling, quinazolines, synthetic method
ID: J60-Y2010-0050