An Expedient Three-Component Synthesis of Tertiary Benzylamines
Erwan Le Gall*, Alexandre Decompte, Thierry Martens, Michel Troupel
*Électrochimie et Synthèse Organique, Institut de Chimie et
des Matériaux Paris-Est, UMR 7182 CNRS - Université Paris Est, 2-8 rue Henri
Dunant, 94320 Thiais, France, Email: legall
glvt-cnrs.fr
E. Le Gall, A. Decompte, T. Martens, M. Troupel, Synthesis, 2010, 249-254.
Abstract
A Mannich-like zinc-mediated three-component reaction of aromatic halides, amines, and paraformaldehyde allows the straightforward synthesis of a range of functionalized tertiary benzylamines. This procedure involves the in situ formation of arylzinc reagents.
see article for more examples
C. Haurena, E. Le Gall, S. Sengmany, T. Martens, M. Troupel, J. Org. Chem., 2010, 75, 2645-2650.
Key Words
benzylamines (amination, arylation), multicomponent reactions, catalysis, zinc, organometallic reagents
ID: J66-Y2010-0090
