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An Expedient Three-Component Synthesis of Tertiary Benzylamines

Erwan Le Gall*, Alexandre Decompte, Thierry Martens, Michel Troupel

*Électrochimie et Synthèse Organique, Institut de Chimie et des Matériaux Paris-Est, UMR 7182 CNRS - Université Paris Est, 2-8 rue Henri Dunant, 94320 Thiais, France, Email:

E. Le Gall, A. Decompte, T. Martens, M. Troupel, Synthesis, 2010, 249-254.

DOI: 10.1055/s-0029-1217108


A Mannich-like zinc-mediated three-component reaction of aromatic halides, amines, and paraformaldehyde allows the straightforward synthesis of a range of functionalized tertiary benzylamines. This procedure involves the in situ formation of arylzinc reagents.

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A Straightforward Three-Component Synthesis of α-Amino Esters Containing a Phenylalanine or a Phenylglycine Scaffold

C. Haurena, E. Le Gall, S. Sengmany, T. Martens, M. Troupel, J. Org. Chem., 2010, 75, 2645-2650.

Key Words

benzylamines (amination, arylation), multicomponent reactions, catalysis, zinc, organometallic reagents

ID: J66-Y2010-0090