Palladium-Catalyzed One-Pot Synthesis of 4-Aryl-1H-1,2,3-triazoles from anti-3-Aryl-2,3-dibromopropanoic Acids and Sodium Azide

Wensheng Zhang, Chunxiang Kuang*, Qing Yang

*Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, P. R. of China, Email: kuangcxtongji.edu.cn

W. Zhang, C. Kuang, Q. Yang, Synthesis, 2010, 283-287.

DOI: 10.1055/s-0029-1217097

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Abstract

4-Aryl-1H-1,2,3-triazoles were synthesized from anti-3-aryl-2,3-dibromopropanoic acids and sodium azide by a one-pot method using N,N-dimethylformamide as solvent in the presence of Pd₂(dba)₃ and Xantphos.

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proposed mechanism

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The Use of Calcium Carbide in the Synthesis of 1-Monosubstituted Aryl 1,2,3-Triazole via Click Chemistry

Y. Jiang, C. Kuang, Q. Yang, Synlett, 2009, 3163-3166.

Copper(I) Iodide-Catalyzed Synthesis of 4-Aryl-1H-1,2,3-triazoles from anti-3-Aryl-2,3-dibromopropanoic Acids and Sodium Azide

Y. Jiang, C. Kuang, Q. Yang, Synthesis, 2010, 4256-4260.

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Key Words

1H-1,2,3-triazole, 1,2,3-triazoles, anti-3-aryl-2,3-dibromopropanoic acids, sodium azide, Pd₂(dba)₃, one-pot

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ID: J66-Y2010-0140