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Pd-Catalyzed Intramolecular Acylation of Aryl Bromides via C-H Functionalization: A Highly Efficient Synthesis of Benzocyclobutenones

Paula Álvarez-Bercedo, Areli Flores-Gaspar, Arkaitz Correa and Ruben Martin*

*Institute of Chemical Research of Catalonia (ICIQ), Av. Pasos Catalans 16, 43007 Tarragona, Spain, Email:

P. Álvarez-Bercedo, A. Flores-Gaspar, A. Correa, R. Martin, J. Am. Chem. Soc., 2010, 132, 466-467.

DOI: 10.1021/ja909811t


A palladium-catalyzed intramolecular acylation of aldehydes with aryl bromides via C-H functionalization is distinguished by a remarkable functional group tolerance and hence enables the synthesis of various highly functionalized benzocyclobutenones from simple and easily accessible precursors.

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ID: J48-Y2010-0180