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Conversion of Oximes to Carbonyl Compounds with 2-Nitro-4,5-dichloropyridazin-3(2H)-one

Bo Ram Kim, Hyung-Geun Lee, Eun Jung Kim, Sang-Gyeong Lee* and Yong-Jin Yoon*

*Department of Chemistry & Environmental Biotechnology National Core Research Center, Research Institute of Natural Sciences, Gyeongsang National University, Jinju 660-701, Korea, Email:

B. R. Kim, H.-G. Lee, E. J. Kim, S.-G. Lee, Y.-J. Yoon, J. Org. Chem., 2010, 75, 484-486.

DOI: 10.1021/jo902356e


Various aliphatic and aromatic oximes were converted to their corresponding aldehydes and ketones in good to excellent yields in the presence of 2-nitro-4,5-dichloropyridazin-3(2H)-one under microwave irradition. It is noteworthy that the reaction is conducted under neutral, mild, and eco-friendly condition.

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Key Words

Ketones, Aldehydes, Microwave Synthesis, Green Chemistry

ID: J42-Y2010-0240