Preparation and Utility of Trihaloethyl Imidates: Useful Reagents for the Synthesis of Amidines
Stéphane Caron*, Lulin Wei, Jasmin Douville and Arun Ghosh
*Chemical R&D, Pfizer Global R&D, MS-8118D/4002, Eastern
Point Road, Groton, Connecticut 06340, Email: stephane.caron
pfizer.com
S. Caron, L. Wei, J. Douville, A. Ghosh, J. Org. Chem., 2010, 75, 945-947.
DOI: 10.1021/jo902159z
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Abstract
2,2,2-Trifluoro- and trichloroethyl imidates, which are easily prepared by reaction of a nitrile and a trihaloethanol in the presence of HCl, are excellent reagents for the preparation of amidines under mild reaction conditions.
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Key Words
Pinner Reaction, Imino Ethers, Amidines
ID: J42-Y2010-0320
