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Preparation and Utility of Trihaloethyl Imidates: Useful Reagents for the Synthesis of Amidines

Stéphane Caron*, Lulin Wei, Jasmin Douville and Arun Ghosh

*Chemical R&D, Pfizer Global R&D, MS-8118D/4002, Eastern Point Road, Groton, Connecticut 06340, Email:

S. Caron, L. Wei, J. Douville, A. Ghosh, J. Org. Chem., 2010, 75, 945-947.

DOI: 10.1021/jo902159z

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2,2,2-Trifluoro- and trichloroethyl imidates, which are easily prepared by reaction of a nitrile and a trihaloethanol in the presence of HCl, are excellent reagents for the preparation of amidines under mild reaction conditions.

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Key Words

Pinner Reaction, Imino Ethers, Amidines

ID: J42-Y2010-0320