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A Simple, Advantageous Synthesis of 5-Substituted 1H-Tetrazoles

Biswanath Das*, Cheruku Ravindra Reddy, Duddukuri Nandan Kumar, Martha Krishnaiah, Ravirala Narender

*Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email: biswanathdasyahoo.com

B. Das, C. R. Reddy, D. N. Kumar, M. Krishnaiah, R. Narender, Synlett, 2010, 391-394.

DOI: 10.1055/s-0029-1219150


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Abstract

Treatment of organic nitriles with NaN3 in the presence of iodine or silica-supported sodium hydrogen sulfate as a heterogeneous catalyst enables an advantageous synthesis of 5-substituted 1H-tetrazoles.

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Key Words

5-substitued 1H-tetrazole, tetrazoles, organic nitriles, NaN3, NaHSO4 • SiO2, [3+2] cycloaddition, heterogeneous conditions


ID: J60-Y2010-0330