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Homogeneous Gold-Catalyzed Oxidative Carboheterofunctionalization of Alkenes

Guozhu Zhang, Li Cui, Yanzhao Wang and Liming Zhang*

*Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California 93106, Email:

G. Zhang, L. Cui, Y. Wang, L. Zhang, J. Am. Chem. Soc., 2010, 132, 1474-1475.

DOI: 10.1021/ja909555d


Homogeneous carboamination, carboalkoxylation and carbolactonization of terminal alkenes are realized via oxidative gold catalysis, providing expedient access to various substituted N- or O-heterocycles. Deuterium-labeling studies established the nature of the alkene functionalization and the indispensible role of Au(I)/Au(III) catalysis.

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Key Words

Pyrrolidines, Tetrahydrofurans, Lactones

ID: J48-Y2010-0380