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Zinc-Catalyzed Reduction of Amides: Unprecedented Selectivity and Functional Group Tolerance

Shoubhik Das, Daniele Addis, Shaolin Zhou, Kathrin Junge and Matthias Beller*

*Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany, Email:

S. Das, D. Addis, S. Zhou, K. Junge, M. Beller, J. Am. Chem. Soc., 2010, 132, 1770-1771.

DOI: 10.1021/ja910083q


A zinc-catalyzed reduction of tertiary amides shows remarkable chemoselectivity and substrate scope tolerating ester, ether, nitro, cyano, azo, and keto substituents.

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Key Words

Reduction of Amides, Triethoxysilane

ID: J48-Y2010-0390