Rapid Decarboxylative Allylation of Nitroalkanes
Alexander J. Grenning and Jon A. Tunge*
*Department of Chemistry, The University of Kansas, Lawrence,
Kansas 66045, Email:
tunge
ku.edu
A. J. Grenning, J.A. Tunge, Org. Lett., 2010, 12, 740-742.
DOI: 10.1021/ol902828p
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Abstract
Allyl nitroacetates undergo decarboxylative allylation to provide tertiary nitroalkanes in high yield within several minutes under ambient conditions. The preparation of substrate allyl nitroacetates by tandem Knoevenagel/Diels-Alder sequences allows the facile synthesis of relatively complex substrates that undergo diastereoselective decarboxylative allylation.
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Key Words
ID: J54-Y2010-0400
