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Iron(III)-Catalyzed Four-Component Coupling Reaction of 1,3-Dicarbonyl Compounds, Amines, Aldehydes, and Nitroalkanes: A Simple and Direct Synthesis of Functionalized Pyrroles

Sukhendu Maiti, Srijit Biswas and Umasish Jana*

*Department of Chemistry, Jadavpur University, Kolkata 700032, West Bengal, India, Email:

S. Maiti, S. Biswas, U. Jana, J. Org. Chem., 2010, 75, 1674-1683.

DOI: 10.1021/jo902661y (free Supporting Information)

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An iron(III)-catalyed four-component coupling reactions of 1,3-dicarbonyl compounds, amines, aromatic aldehydes, and nitroalkanes without an inert atmosphere provides highly substituted pyrroles in good yields. Notably, this method is very cheap, straightforward, and environmentally friendly compared to existing methods.

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Key Words

Pyrroles, Multicomponent Reactions

ID: J42-Y2010-0570