Organic Chemistry Portal

Abstracts

Search:

A Highly Efficient Palladium/Copper Cocatalytic System for Direct Arylation of Heteroarenes: An Unexpected Effect of Cu(Xantphos)I

Jinkun Huang*, Johann Chan, Ying Chen, Christopher J. Borths, Kyle D. Baucom, Robert D. Larsen and Margaret M. Faul

*Chemical Process Research and Development, Amgen Inc., Thousand Oaks, California 91320, Email: jhuangamgen.com

J. Huang, J. Chan, Y. Chen, C. J. Borths, K. D. Baucom, R. D. Larsen, M. M. Faul, J. Am. Chem. Soc., 2010, 132, 3674-3675.

DOI: 10.1021/ja100354j (free Supporting Information)


Abstract

A highly efficient Pd/Cu-catalyzed C-H arylation method for a range of heterocycles has been discovered. The efficiency and low loading of a combination of a palladium catalyst and a well-defined copper cocatalyst together with the mild reaction conditions demonstrate this method to be practically useful and mechanistically interesting.


see article for more examples


proposed mechanism



Key Words

Benzothiazoles, Benzoxazoles


ID: J48-Y2010-0600