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An Efficient, One-Pot, Multicomponent Synthesis of β-Acetamido Carbonyl Compounds Using Cyanuric Chloride in an Aqueous Medium

Biswanath Das*, Malampati Srilatha, Boyapati Veeranjaneyulu, Bethapudi Rama Rao

*Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email:

B. Das, M. Srilatha, B. Veeranjaneyulu, B. R. Rao, Synthesis, 2010, 803-806.

DOI: 10.1055/s-0029-1218584


A one-pot, three-component reaction between an aromatic aldehyde, an enolizable ketone or a β-keto ester, and a nitrile in the presence of acetyl chloride is accomplished efficiently using cyanuric chloride in an aqueous medium to give the corresponding β-acetamido ketone or ester in high yield.

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Key Words

β-acetamido ketones, β-acetamido esters, multicomponent reactions, cyanuric chloride, aqueous medium

ID: J66-Y2010-0620