Gold(III)-Catalyzed Synthesis of Isoxazoles by Cycloisomerization of α,β-Acetylenic Oximes
C. Praveen, A. Kalyanasundaram, P. T. Perumal*
*Organic Chemistry Division, Central Leather Research Institute, Adyar, Chennai 600 020, India, Email: ptperumalgmail.com
C. Praveen, A. Kalyanasundaram, P. T. Perumal, Synlett, 2010, 777-781.
AuCl3-catalyzed cycloisomerization of α,β-acetylenic oximes leads to substituted isoxazoles in very good yields under moderate reaction conditions. The methodology is amenable for the selective synthesis of 3-substituted, 5-substituted or 3,5-disubstituted isoxazoles.
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α,β-acetylenic oximes, gold(III) chloride, cycloisomerization, isoxazoles