N,N'-Di-Boc-Substituted Thiourea as a Novel and Mild Thioacylating Agent Applicable for the Synthesis of Thiocarbonyl Compounds
Biao-Lin Yin*, Zhao-Gui Liu, Jian-Cun Zhang, Zheng-Rong Li
*School of Chemistry and Chemical Engineering, South China
University of Technology, Guangzhou, 510640, P. R. of China, Email: blyin
scut.edu.cn
B.-L. Yin, Z.-G. Liu, J.-C. Zhang, Z.-R. Li, Synthesis, 2010, 991-999.
DOI: 10.1055/s-0029-1219273
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Abstract
Stable and readily available N,N'-di-Boc-substituted thiourea can be used as a mild thioacylating agent when activated with trifluoroacetic acid anhydride. Through thioacylation of nucleophiles, such as amines, alcohols, thiols, sodium benzenethiolate, and sodium malonates, a series of thiocarbonyl compounds were prepared with good chemical selectivity and functional group tolerance.
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Key Words
N,N'-di-Boc-substituted thiourea, thioacylating agent, thiocarbonyl, thioureas, thiocarbamates
ID: J66-Y2010-0760
