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A Concise Synthesis of Substituted Thiourea Derivatives in Aqueous Medium

Mahagundappa R. Maddani and Kandikere R. Prabhu*

*Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, Karnataka, India, Email: prabhuorgchem.iisc.ernet.in

M. R. Maddani, K. R. Prabhu, J. Org. Chem., 2010, 75, 2327-2332.

DOI: 10.1021/jo1001593


Abstract

A simple condensation between amines and carbon disulfide in aqueous medium allows an efficient synthesis of symmetrical and unsymmetrical substituted thiourea derivatives. This protocol works smoothly with aliphatic primary amines to afford various di- and trisubstituted thiourea derivatives.

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Key Words

Thiourea Derivatives, Green Chemistry


ID: J42-Y2010-0850