Difluoromethyl 2-Pyridyl Sulfone: A New gem-Difluoroolefination Reagent for Aldehydes and Ketones
Yanchuan Zhao, Weizhou Huang, Lingui Zhu and Jinbo Hu*
*Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China, Email: jinbohusioc.ac.cn
Y. Zhao, W. Huang, L. Zhu, J. Hu, Org. Lett., 2010, 12, 1444-1447.
Difluoromethyl 2-pyridyl sulfone acts as a novel and efficient gem-difluoroolefination reagent for both aldehydes and ketones. A fluorinated sulfinate intermediate in the reaction is relatively stable and can be observed by 19F NMR and trapped with CH3I.
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M. Hu, Z. He, B. Gao, L. Li, C. Ni, J. Hu, J. Am. Chem. Soc., 2013, 135, 17302-17305.