Total Regioselective Transformation of Aromatic Aziridine 2-Carboxamides into 2-Aminoamides Promoted by Active Manganese
José M. Concellón*, Humberto Rodríguez-Solla, Vicente del Amo and Pamela Díaz
*Departamento de Qumica Orgnica e Inorgnica, Facultad de
Qumica, Universidad de Oviedo, Julin Clavera 8, 33071 Oviedo, Spain, Email: jmcg
uniovi.es
J. M. Concellón, H. Rodríguez-Solla, V. del Amo, P. Díaz, J. Org. Chem., 2010, 75, 2407-2410.
DOI: 10.1021/jo902708x
Abstract
A totally regioselective transformation of aromatic N-4-methoxyphenylaziridine 2-carboxamides into 2-aminoamides is promoted by active manganese (Mn*). α-Amino ketones can be readily obtained by reaction of morpholine-derived 2-aminoamides with organolithium compounds.
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Key Words
α-amino amides, manganese, reduction
ID: J42-Y2010-0890
