Highly Efficient Cs2CO3-Catalyzed 1,4-Addition of Me3SiCN to Enones with Water as the Additive
Jingya Yang, Yongbin Shen, Fu-Xue Chen*
*Department of Applied Chemistry, School of Chemical Engineering & the Environment, Beijing Institute of Technology, No. 5 South Zhongguancun Street, Haidian District, Beijing 100081, P. R. of China, Email: fuxue.chenbit.edu.cn
J. Yang, Y. Shen, F.-X. Chen, Synthesis, 2010, 1325-1333.
A facile and efficient 1,4-addition of Me3SiCN to enones has been achieved with perfect regioselectivity using Cs2CO3 as catalyst in the presence of H2O as an additive. β-Cyanoketones are obtained in excellent yields within one to five hours. Both aromatic and aliphatic enones are suitable substrates.
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The Highly Efficient 1,4-Addition of TMSCN to Aromatic Enones Catalyzed by CsF with Water as the Additive
J. Yang, Y. Wang, S. Wu, F.-X. Chen, Synlett, 2009, 3365-3367.
1,4-addition reaction, catalysis, enones, nitriles, regioselectivity