Organic Chemistry Portal



Cobalt Catalysis at the Crossroads: Cobalt-Catalyzed Alder−Ene Reaction versus [2 + 2] Cycloaddition

Gerhard Hilt*, Anna Paul and Jonas Treutwein

*Fachbereich Chemie, Philipps-Universitt Marburg, Hans-Meerwein-Strasse, 35043 Marburg, Germany, Email:

G. Hilt, A. Paul, J. Treutwein, Org. Lett., 2010, 12, 1536-1539.

DOI: 10.1021/ol100266u

see article for more reactions


Cobalt-catalyzed transformations of cyclic alkenes such as cyclopentene and cycloheptene with internal alkynes led to a chemoselective Alder-ene or a [2 + 2] cycloaddition reaction depending on the electronic nature of the alkyne and the bite angle of a bidentate phosphine ligand used.

see article for more examples

Key Words

Cyclobutenes, Cyclopentanes

ID: J54-Y2010-0960