Organic Chemistry Portal



The First One-Pot Synthesis of Morita-Baylis-Hillman Adducts Starting Directly from Alcohols

Lal Dhar Singh Yadav*, Vishnu Prabhakar Srivastava, Rajesh Patel

*Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad 211002, India, Email:

L. D. S. Yadav, V. P. Srivasta, R. Patel, Synlett, 2010, 1047-1050.

DOI: 10.1055/s-0029-1219577


Silica gel-DABCO catalyzed oxidation of alcohols to aldehydes with chloramine-T followed by their Morita-Baylis-Hillman reaction with acrylonitrile or methyl acrylate gives good overall yields of the corresponding Morita-Baylis-Hillman adducts. The present work opens up a new and efficient synthetic route to Morita-Baylis-Hillman adducts directly from alcohols in a one-pot operation.

see article for more examples

Key Words

oxidation, C-C bond formation, alcohols, chloramine-T, silica gel-DABCO, Baylis-Hillmann reaction, Morita-Baylis-Hillman adducts

ID: J60-Y2010-1010