The First One-Pot Synthesis of Morita-Baylis-Hillman Adducts Starting Directly from Alcohols
Lal Dhar Singh Yadav*, Vishnu Prabhakar Srivastava, Rajesh Patel
*Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad 211002, India, Email: ldsyadavhotmail.com
L. D. S. Yadav, V. P. Srivasta, R. Patel, Synlett, 2010, 1047-1050.
Silica gel-DABCO catalyzed oxidation of alcohols to aldehydes with chloramine-T followed by their Morita-Baylis-Hillman reaction with acrylonitrile or methyl acrylate gives good overall yields of the corresponding Morita-Baylis-Hillman adducts. The present work opens up a new and efficient synthetic route to Morita-Baylis-Hillman adducts directly from alcohols in a one-pot operation.
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