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Direct Synthesis of Arylketones by Nickel-Catalyzed Addition of Arylboronic Acids to Nitriles

Ying-Chieh Wong, Kanniyappan Parthasarathy and Chien-Hong Cheng*

*Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, Email:

Y.-C. Wong, K. Parthasarathy, C.-H. Cheng, Org. Lett., 2010, 12, 1736-1739.

DOI: 10.1021/ol1003252 (free Supporting Information)


A convenient and efficient method allows the synthesis of various arylketones by nickel-catalyzed addition of arylboronic acids to nitriles. A catalytic cycle involving Ni(II) species as the catalytic intermediates is proposed.

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Key Words

Aryl Ketones

ID: J54-Y2010-1070