Pd-Catalyzed Domino Synthesis of Internal Alkynes Using Triarylbismuths as Multicoupling Organometallic Nucleophiles
Maddali L. N. Rao*, Deepak N. Jadhav and Priyabrata Dasgupta
*Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208 016, India, Email: maddaliiitk.ac.in
M. L. N. Rao, D. N. Jadhav, P. Dasgupta, Org. Lett., 2010, 12, 2048-2051.
DOI: 10.1021/ol1004164 (free Supporting Information)
A palladium-catalyzed domino coupling reaction of 1,1-dibromo-1-alkenes with triarylbismuth nucleophiles furnishes disubstituted alkynes directly. The couplings are very fast, affording high yields of alkynes in a short reaction time.
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