Organic Chemistry Portal

Abstracts

Search:

Pd-Catalyzed Domino Synthesis of Internal Alkynes Using Triarylbismuths as Multicoupling Organometallic Nucleophiles

Maddali L. N. Rao*, Deepak N. Jadhav and Priyabrata Dasgupta

*Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208 016, India, Email: maddaliiitk.ac.in

M. L. N. Rao, D. N. Jadhav, P. Dasgupta, Org. Lett., 2010, 12, 2048-2051.

DOI: 10.1021/ol1004164 (free Supporting Information)


Abstract

A palladium-catalyzed domino coupling reaction of 1,1-dibromo-1-alkenes with triarylbismuth nucleophiles furnishes disubstituted alkynes directly. The couplings are very fast, affording high yields of alkynes in a short reaction time.

see article for more examples



Key Words

Alkynylations, Internal Alkynes


ID: J54-Y2010-1260