Indium-Catalyzed N-Formylation of Amines under Solvent-Free Conditions

Joong-Gon Kima, Doo Ok Jang*

*Department of Chemistry, Yonsei University, Wonju 220-710, South Korea, Email: dojangyonsei.ac.kr

J.-G. Kima, D. O. Jang, Synlett, 2010, 1231-1234.

DOI: 10.1055/s-0029-1219784

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Abstract

A simple, mild method for N-formylation in the presence of indium metal as a catalyst under solvent-free conditions is applicable to the chemoselective reaction of amines and α-amino acid esters without epimerization.

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Key Words

amine, formylation, formic acid, indium, ethanol­amine, formylamino ester, amides, solvent-free, green chemistry

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ID: J60-Y2010-1280