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Mild Conditions for Copper-Catalyzed N-Arylation of Imidazoles

Huaming Chen, Deping Wang, Xianyang Wang, Wenlong Huang, Qian Cai, Ke Ding*

*Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou International Business Incubator D-10, Guangzhou Science Park, Guangzhou 510663, P. R. of China, Email:

H. Chen, D. Wang, X. Wang, W. Huang, Q. Cai, K. Ding, Synthesis, 2010, 1505-1511.

DOI: 10.1055/s-0029-1218691


An efficient copper(I) bromide catalyzed N-arylation of azoles with a variety of aromatic bromides and iodides under mild conditions displayed great functional group compatibility and excellent reactive selectivity.

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Key Words

copper, aryl halides, imidazoles, azoles, N-arylation

ID: J66-Y2010-1300