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Synthesis of 2H-Indazoles by the [3 + 2] Cycloaddition of Arynes and Sydnones

Chunrui Wu, Yuesi Fang, Richard C. Larock* and Feng Shi

*Department of Chemistry, Iowa State University, Ames, Iowa 50010, Email:

C. Wu, Y. Fang, R. C. Larock, F. Shi, Org. Lett., 2010, 12, 2171-2173.

DOI: 10.1021/ol100586r


A rapid and efficient synthesis of 2H-indazoles, which involves a [3 + 2] dipolar cycloaddition of arynes and sydnones, proceeds under mild reaction conditions in good to excellent yields.

see article for more examples

Synthesis of Indazoles by the [3+2] Cycloaddition of Diazo Compounds with Arynes and Subsequent Acyl Migration

Z. Liu, F. Shi, P. D. G. Martinze, C. Raminelli, R. C. Larock, J. Org. Chem., 2008, 73, 219-226.

Key Words

2H-Indazoles, Huisgen 1,3-dipolar Cycloaddition

ID: J54-Y2010-1340