An Efficient New Method for the Synthesis of Polysubstituted Pyrroles
Biswanath Das*, Gandolla Chinna Reddy, Penagaluri Balasubramanyam, Boyapati Veeranjaneyulu
*Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email: biswanathdasyahoo.com
B. Das, G. C. Reddy, P. Balasubramanyam, B. Veeranjaneyulu, Synthesis, 2010, 1625-1628.
A three-component reactions of arylacyl bromides, amines, and dialkyl acetylenedicarboxylate in the presence of iron(III) chloride as a catalyst at room temperature afforded polysubstituted pyrroles in high yields.
see article for more examples
B. Das, N. Bhunia, M. Lingaiah, Synthesis, 2011, 3471-3474.