An Efficient New Method for the Synthesis of Polysubstituted Pyrroles

Biswanath Das*, Gandolla Chinna Reddy, Penagaluri Balasubramanyam, Boyapati Veeranjaneyulu

*Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email: biswanathdasyahoo.com

B. Das, G. C. Reddy, P. Balasubramanyam, B. Veeranjaneyulu, Synthesis, 2010, 1625-1628.

DOI: 10.1055/s-0029-1218703

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Abstract

A three-component reactions of arylacyl bromides, amines, and dialkyl acetylenedicarboxylate in the presence of iron(III) chloride as a catalyst at room temperature afforded polysubstituted pyrroles in high yields.

see article for more examples

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A Simple and Efficient Metal-Free Synthesis of Tetrasubstituted Pyrroles by Iodine-Catalyzed Four-Component Coupling Reaction of Aldehydes, Amines, Dialkyl Acetylenedicarboxylates, and Nitromethane

B. Das, N. Bhunia, M. Lingaiah, Synthesis, 2011, 3471-3474.

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Key Words

polysubstituted pyrroles, multicomponent reactions, iron(III) chloride

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ID: J66-Y2010-1350