Tetrapropylammonium Perruthenate, Pr₄N⁺RuO₄^-, TPAP: A Catalytic Oxidant for Organic Synthesis

Steven V. Ley*, Joanne Norman, William P. Griffith, Stephen P. Marsden

*Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, England, Email: svl1000cam.ac.uk

S. B. Ley, J. Norman, W. P. Griffith, S. P. Marsden, Synthesis, 1994, 639-666.

DOI: 10.1055/s-1994-25538

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Abstract

Tetrapropylammonium perruthenate enables oxidations of a wide range of molecules including examples of both double oxidations and selective oxidations. Mechanistic studies and general experimental procedures are reported. In addition several interesting developments in the chemistry of this reagent are outlined: heteroatom oxidation, cleavage reactions and use in sequential reaction processes.

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Key Words

Tetrapropylammonium Perruthenate, N-Methylmorpholine-N-Oxide, Ketones, Aldehydes

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ID: J66-Y1994-790