Organic Chemistry Portal



Tetrapropylammonium Perruthenate, Pr4N+RuO4-, TPAP: A Catalytic Oxidant for Organic Synthesis

Steven V. Ley*, Joanne Norman, William P. Griffith, Stephen P. Marsden

*Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, England, Email:

S. B. Ley, J. Norman, W. P. Griffith, S. P. Marsden, Synthesis, 1994, 639-666.

DOI: 10.1055/s-1994-25538

see article for more reactions


Tetrapropylammonium perruthenate enables oxidations of a wide range of molecules including examples of both double oxidations and selective oxidations. Mechanistic studies and general experimental procedures are reported. In addition several interesting developments in the chemistry of this reagent are outlined: heteroatom oxidation, cleavage reactions and use in sequential reaction processes.

see article for more examples

Key Words

Tetrapropylammonium Perruthenate, N-Methylmorpholine-N-Oxide, Ketones, Aldehydes

ID: J66-Y1994-790