Facile Synthesis of Polysubstituted Oxazoles via A Copper-Catalyzed Tandem Oxidative Cyclization
Changfeng Wan, Jintang Zhang, Sujing Wang, Jinmin Fan and Zhiyong Wang*
*Hefei National Laboratory for Physical Sciences at
Microscale, CAS Key Laboratory of Soft Matter Chemistry and Department of
Chemistry, University of Science and Technology of China, Hefei, 230026, P. R.
China, Email: zwang3
ustc.edu.cn
C. Wang, J. Zhang, S. Wang, J. Fan, Z. Wang, Org. Lett., 2010, 12, 2338-2341.
DOI: 10.1021/ol100688c
Abstract
A highly efficient copper-catalyzed tandem oxidative cyclization gives polysubstituted oxazoles from readily available starting materials under mild conditions. This is an attractive alternative method for the synthesis of oxazole derivatives.
see article for more examples
C. Wan, L. Gao, Q. Wang, J. Zhang, Z. Wang, Org. Lett., 2010, 12, 3902-9305.
Key Words
Oxazoles, tert-Butyl hydroperoxide, Iodine
ID: J54-Y2010-1400
