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Pd-Catalyzed Cross-Coupling Reactions of Amides and Aryl Mesylates

Karin Dooleweerdt, Brett P. Fors and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

K. Dooleweerdt, B. P. Fors, S. L. Buchwald, Org. Lett., 2010, 12, 2350-2353.

DOI: 10.1021/ol100720x


A catalyst, based on a biarylphosphine ligand, for the Pd-catalyzed cross-coupling reactions of amides and aryl mesylates allows the transformation of an array of aryl and heteroaryl mesylates into the corresponding N-aryl amides in good yields.

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Pd-Catalyzed Amidations of Aryl Chlorides Using Monodentate Biaryl Phosphine Ligands: A Kinetic, Computational, and Synthetic Investigation

T. Ikawa, T. E. Barder, M. R. Biscoe, S. L. Buchwald, J. Am. Chem. Soc., 2007, 129, 13001-13007.

Key Words


ID: J54-Y2010-1430