An Efficient One-Pot Synthesis of Oxime Ethers from Alcohols Using Triphenylphosphine/Carbon Tetrachloride
Mohammad Navid Soltani Rad*, Ali Khalafi-Nezhad, Fatemeh Karimitabar, Somayeh Behrouz
*Department of Chemistry, Faculty of Basic Sciences, Shiraz
University of Technology, Shiraz 71555-313, Iran, Email: soltani
sutech.ac.ir
M. N. S. Rad, A. A. Khalafi-Nezhad, F. Karimitabar, S. Behrouz, Synthesis, 2010, 1724-1730.
DOI: 10.1055/s-0029-1218711
Abstract
Treatment of alcohols with a mixture of triphenylphosphine, carbon tetrachloride, oxime, and DBU in the presence of catalytic amounts of tetrabutylammonium iodide in refluxing acetonitrile regioselectively furnishes the corresponding O-alkyl ethers in good yields.
see article for more examples
Key Words
oxime, alcohol, O-alkylation, triphenylphosphine, carbon tetrachloride, DBU
ID: J66-Y2010-1470
