Bromodimethylsulfonium Bromide-ZnCl₂: A Mild and Efficient Catalytic System for Beckmann Rearrangement

Lal Dhar S. Yadav*, Rajesh Patel, Vishnu P. Srivastava

*Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad 211002, India, Email: ldsyadavhotmail.com

L. D. S. Yadav, R. Patel, V. P. Srivastava, Synthesis, 2010, 1771-1776.

DOI: 10.1055/s-0029-1218730

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Abstract

A combination of bromodimethylsulfonium bromide with zinc chloride is an excellent catalytic system for liquid-phase Beckmann rearrangement of various ketoximes into the corresponding amides/lactams in acetonitrile at reflux temperature with good to excellent yields.

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Key Words

Beckmann rearrangement, ketoximes, amides, bromodimethylsulfonium bromide (BDMS), catalytic process, Lewis acids

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ID: J66-Y2010-1480