Organic Chemistry Portal



Bromodimethylsulfonium Bromide-ZnCl2: A Mild and Efficient Catalytic System for Beckmann Rearrangement

Lal Dhar S. Yadav*, Rajesh Patel, Vishnu P. Srivastava

*Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad 211002, India, Email:

L. D. S. Yadav, R. Patel, V. P. Srivastava, Synthesis, 2010, 1771-1776.

DOI: 10.1055/s-0029-1218730


A combination of bromodimethylsulfonium bromide with zinc chloride is an excellent catalytic system for liquid-phase Beckmann rearrangement of various ketoximes into the corresponding amides/lactams in acetonitrile at reflux temperature with good to excellent yields.

see article for more examples

Key Words

Beckmann rearrangement, ketoximes, amides, bromodimethylsulfonium bromide (BDMS), catalytic process, Lewis acids

ID: J66-Y2010-1480