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Sulfur Modification of Au via Treatment with Piranha Solution Provides Low-Pd Releasing and Recyclable Pd Material, SAPd

Naoyuki Hoshiya, Masahiko Shimoda, Hideki Yoshikawa, Yoshiyuki Yamashita, Satoshi Shuto and Mitsuhiro Arisawa*

*Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo 060-0812 Japan, Email: arisawapharm.hokudai.ac.jp

N. Hoshiya, M. Shimoda, H. Yoshikawa, Y. Yamashita, S. Shuto, M. Arisawa, J. Am. Chem. Soc., 2010, 132, 7270-7272.

DOI: 10.1021/ja9100084 (free Supporting Information)


Abstract

Palladium immobilized on a sulfur-modified gold surface (SAPd) offers a high recyclability. Because this material leaches extremely low levels of Pd into the reaction mixture, removal of the residual Pd is unnecessary using SAPd, even in syntheses involving pharmaceutical ingredients.

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Key Words

Suzuki Coupling, Biaryls, Green Chemistry


ID: J48-Y2010-1510