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Magnesium Metal-Mediated Reductive Trifluoromethylation of Aldehydes with Phenyl Trifluoromethyl Sulfone

Yanchuan Zhao, Jieming Zhu, Chuanfa Ni, Jinbo Hu*

*Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, P. R. of China, Email:

Y. Zhao, J. Zhu, C. Ni, J. Hu, Synthesis, 2010, 1899-1904.

DOI: 10.1055/s-0029-1218752


Mercury(II) chloride efficiently activates magnesium metal to induce a desulfonylative trifluoromethylation process. The new reductive trifluoromethylation provides an alternative method for efficient trifluoromethylation of non-enolizable or enolizable aldehydes with readily available phenyl trifluoromethyl sulfone reagent.

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Key Words

alkylations, aldehydes, alcohols, trifluoromethylations, phenyl trifluoromethyl sulfone, magnesium

ID: J66-Y2010-1540