Magnesium Metal-Mediated Reductive Trifluoromethylation of Aldehydes with Phenyl Trifluoromethyl Sulfone
Yanchuan Zhao, Jieming Zhu, Chuanfa Ni, Jinbo Hu*
*Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, P. R. of China, Email: jinbohusioc.ac.cn
Y. Zhao, J. Zhu, C. Ni, J. Hu, Synthesis, 2010, 1899-1904.
Mercury(II) chloride efficiently activates magnesium metal to induce a desulfonylative trifluoromethylation process. The new reductive trifluoromethylation provides an alternative method for efficient trifluoromethylation of non-enolizable or enolizable aldehydes with readily available phenyl trifluoromethyl sulfone reagent.
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Nucleophilic Perfluoroalkylation of Imines and Carbonyls: Perfluoroalkyl Sulfones as Efficient Perfluoroalkyl-Transfer Motifs
G. K. S. Prakash, Y. Wang, R. Mogi, J. Hu, T. Mathew, G. A. Olah, Org. Lett., 2010, 12, 2932-2935.
alkylations, aldehydes, alcohols, trifluoromethylations, phenyl trifluoromethyl sulfone, magnesium