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Expeditious Synthesis of Highly Substituted Indolizinones via a Palladium-Catalyzed Domino Sequence

Ikyon Kim* and Kyungsun Kim

*College of Pharmacy, Yonsei University, 162-1 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea, Email: ikyonkimyonsei.ac.kr

I. Kim, K. Kim, Org. Lett., 2010, 12, 2500-2503.

DOI: 10.1021/ol1006778


Abstract

A palladium-catalyzed domino process involving aminopalladation, reductive elimination, and 1,2-shift enables a direct one-pot approach to polysubstituted indolizinones from tertiary propargylic alcohols.

see article for more examples

proposed reaction mechanism



A Highly Efficient Catalyst-Free Cycloisomerization Approach to Indolizinones

I. Kim, J. Choi, S. Lee, G. H. Lee, Synlett, 2008, 2334-2338.


Key Words

Indolizinones


ID: J54-Y2010-1550