Expeditious Synthesis of Highly Substituted Indolizinones via a Palladium-Catalyzed Domino Sequence
Ikyon Kim* and Kyungsun Kim
*College of Pharmacy, Yonsei University, 162-1 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea, Email: ikyonkimyonsei.ac.kr
I. Kim, K. Kim, Org. Lett., 2010, 12, 2500-2503.
DOI: 10.1021/ol1006778
Abstract
A palladium-catalyzed domino process involving aminopalladation, reductive elimination, and 1,2-shift enables a direct one-pot approach to polysubstituted indolizinones from tertiary propargylic alcohols.
see article for more examples
proposed reaction mechanism
A Highly Efficient Catalyst-Free Cycloisomerization Approach to Indolizinones
I. Kim, J. Choi, S. Lee, G. H. Lee, Synlett, 2008, 2334-2338.
Key Words
ID: J54-Y2010-1550