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Access to 2,5-Diamidopyrroles and 2,5-Diamidofurans by Au(I)-Catalyzed Double Hydroamination or Hydration of 1,3-Diynes

Søren Kramer, Julie L. H. Madsen, Mario Rottländer and Troels Skrydstrup*

*Center for Insoluble Protein Structures (inSPIN), Department of Chemistry and the Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark, Email:

S. Kramer, J. L. H. Madsen, M. Rottländer, T. Skrydstrup, Org. Lett., 2010, 12, 2758-2761.

DOI: 10.1021/ol1008685 (free Supporting Information)

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A Au(I)-catalyzed hydroamination or hydration of 1,3-diynes allows access to 2,5-diamidopyrroles and 2,5-diamidofurans. This method can also be expanded to 2,5-disubstituted furans and 1,2,5-trisubstituted pyrroles.

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Key Words

Pyrroles, Furans

ID: J54-Y2010-1680