Sodium Bromodifluoroacetate: A Difluorocarbene Source for the Synthesis of gem-Difluorocyclopropanes

Kojun Oshiro, Yoshimichi Morimoto, Hideki Amii*

*Department of Chemistry, Graduate School of Science, Kobe University, Nada-ku 1-1, Kobe 657-8510, Japan, Email: amiichem-bio.gunma-u.ac.jp

K. Oshiro, Y. Morimoto, H. Amii, Synthesis, 2010, 2080-2084.

DOI: 10.1055/s-0029-1218754

---

Abstract

Sodium bromodifluoroacetate (BrCF₂CO₂Na) is an effective difluorocarbene source for high-yielding­ synthesis of gem-difluorocyclopropanes and gem-difluorocyclopropenes under mild conditions.

see article for more examples

---

---

Key Words

fluorine, carbenes, cycloaddition, cyclopropanes, cyclopropenes, fluoroalkanes, difluoroalkanes

---

ID: J66-Y2010-1710