Sodium Bromodifluoroacetate: A Difluorocarbene Source for the Synthesis of gem-Difluorocyclopropanes
Kojun Oshiro, Yoshimichi Morimoto, Hideki Amii*
*Department of Chemistry, Graduate School of Science, Kobe
University, Nada-ku 1-1, Kobe 657-8510, Japan, Email: amiichem-bio.gunma-u.ac.jp
K. Oshiro, Y. Morimoto, H. Amii, Synthesis, 2010, 2080-2084.
DOI: 10.1055/s-0029-1218754
Abstract
Sodium bromodifluoroacetate (BrCF2CO2Na) is an effective difluorocarbene source for high-yielding synthesis of gem-difluorocyclopropanes and gem-difluorocyclopropenes under mild conditions.
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Key Words
fluorine, carbenes, cycloaddition, cyclopropanes, cyclopropenes, fluoroalkanes, difluoroalkanes
ID: J66-Y2010-1710