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A Simple and Efficient Approach to the Synthesis of 2-Phenylquinazolines via sp3 C-H Functionalization

Jintang Zhang, Dapeng Zhu, Chenmin Yu, Changfeng Wan and Zhiyong Wang*

*Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, P. R. China, Email:

J. Zhang, D. Zhu, C. Yu, C. Wan, Z. Wang, Org. Lett., 2010, 12, 2841-2843.

DOI: 10.1021/ol100954x

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A facile approach allows the synthesis of 2-phenylquinazolines via a tandem reaction following sp3 C-H functionalization. Twenty-five examples of 2-phenylquinazolines were obtained from easily available 2-aminobenzophenones and benzylic amines with good to excellent yields.

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Key Words

Quinazolines, tert-butyl hydroperoxide

ID: J54-Y2010-1720