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Copper Catalyzed Arylation/C-C Bond Activation: An Approach toward α-Aryl Ketones

Chuan He, Sheng Guo, Li Huang and Aiwen Lei*

*College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P. R. China, Email:

C. He, S. Guo, L. Huang, A. Lei, J. Am. Chem. Soc., 2010, 132, 8273-8275.

DOI: 10.1021/ja1033777 (free Supporting Information)

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β-Diketones can undergo a reaction with aryl halides in the presence of Cu(I) or Cu(II) salts in DMSO using K3PO4 • 3 H2O without ligands to form various α-aryl ketones. H2O assists the C-C activation. This simple, practical method complements classic methods for the rapid construction of C-C bonds to a carbonyl moiety.

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ID: J48-Y2010-1730