Transfer Hydrogenation in Water: Enantioselective, Catalytic Reduction of α-Cyano and α-Nitro Substituted Acetophenones
Omid Soltani, Martin A. Ariger, Henar Vázquez-Villa and Erick M. Carreira*
*Laboratorium für organische Chemie, ETH Zürich, Hönggerberg,
Switzerland, Email: carreira
org.chem.ethz.ch
O. Soltani, M. A. Ariger, H. Vázquez-Villa, E. M. Carreira, Org. Lett., 2010, 12, 2893-2895.
DOI: 10.1021/ol1008894
Abstract
An iridium-catalyzed, chemoselective, asymmetric transfer hydrogenation of α-substituted acetophenones using formic acid as reductant can be performed in water and open to air.
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O. Soltani, M. A. Ariger, E. M. Carreira, Org. Lett., 2009, 11, 4196-4198.
Key Words
reduction of carbonyl compounds, formic acid, β-cyanohydrins, green chemistry
ID: J54-Y2010-1800
