Nucleophilic Perfluoroalkylation of Imines and Carbonyls: Perfluoroalkyl Sulfones as Efficient Perfluoroalkyl-Transfer Motifs
G. K. Surya Prakash*, Ying Wang, Ryo Mogi, Jinbo Hu, Thomas Mathew and George A. Olah
*Donald P. and Katherine B. Loker hydrocarbon Research
Institute and Department of Chemistry, University of Southern California, Los
Angeles, California 90089-1661, Email: gprakash
usc.edu
G. K. S. Prakash, Y. Wang, R. Mogi, J. Hu, T. Mathew, G. A. Olah, Org. Lett., 2010, 12, 2932-2935.
DOI: 10.1021/ol100918d
Abstract
Alkoxide-induced nucleophilic pentafluoroethylation and trifluoromethylation of aldehydes, ketones, and imines using pentafluoroethyl phenyl sulfone and trifluoromethyl phenyl sulfone, respectively, have been successfully achieved.
see article for more examples
Y. Zhao, J. Zhu, C. Ni, J. Hu, Synthesis, 2010, 1899-1904.
Key Words
Perfluorinated Compounds, Alcohols, Benzylamines, α-trifluoromethyl amines
ID: J54-Y2010-1830
