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Two-Component Approach Toward a Fully Substituted N-Fused Pyrrole Ring

Dmitri Chernyak, Cathy Skontos and Vladimir Gevorgyan*

*Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061, Email: vladuic.edu

D. Chernyak, C. Skontos, V. Gevorgyan, Org. Lett., 2010, 12, 3242-3245.

DOI: 10.1021/ol1011949 (free Supporting Information)



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Abstract

An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward various highly functionalized N-fused pyrroloheterocycles in very good yield proceeds via a palladium-catalyzed coupling of aryl halides with propargylic esters or ethers followed by a 5-endo-dig cyclization.


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Gold-Catalyzed 1,2-Migration of Silicon, Tin, and Germanium en Route to C-2 Substituted Fused Pyrrole-Containing Heterocycles

I. V. Seregin, V. Gevorgyan, J. Am. Chem. Soc., 2006, 128, 12050-12051.


Key Words

Indolizines


ID: J54-Y2010-1970