Two-Component Approach Toward a Fully Substituted N-Fused Pyrrole Ring
Dmitri Chernyak, Cathy Skontos and Vladimir Gevorgyan*
*Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061, Email: vladuic.edu
D. Chernyak, C. Skontos, V. Gevorgyan, Org. Lett., 2010, 12, 3242-3245.
DOI: 10.1021/ol1011949 (free Supporting Information)
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An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward various highly functionalized N-fused pyrroloheterocycles in very good yield proceeds via a palladium-catalyzed coupling of aryl halides with propargylic esters or ethers followed by a 5-endo-dig cyclization.
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I. V. Seregin, V. Gevorgyan, J. Am. Chem. Soc., 2006, 128, 12050-12051.