One-Pot Approach for C-C Bond Formation through Ruthenium-Amido Complex Catalyzed Tandem Aldol Reaction/Hydrogenation
Haifeng Sun, Deju Ye, Hualiang Jiang, Kaixian Chen, Hong Liu*
*The Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 201203, P. R. of China, Email: hliumail.shcnc.ac.cn
H. Sun, D. Ye, H. Jiang, K. Chen, H. Liu, Synthesis, 2010, 2577-2582.
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Knoevenagel condensation followed by hydrogenation with triethylamine-formic acid in the presence of a ruthenium-amido complex allowed an α-alkylation of various nitriles with carbonyl compounds in good yields. The reaction tolerated various functional groups, including nitro and chloro groups, and a furan ring.
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ruthenium-amido complex, tandem reaction, aldol reaction, hydrogenation, benzylation, nitriles, formic acid