An Alkynyliodide Cycloaddition Strategy for the Construction of Iodoisoxazoles
James A. Crossley and Duncan L. Browne*
*Department of Chemistry, University of Sheffield, Sheffield S3 7HF, U.K., Email: d.browneshef.ac.uk
J. A. Crossley, D. L. Browne, J. Org. Chem., 2010, 75, 5351-5354.
DOI: 10.1021/jo1011174 (free Supporting Information)
see article for more reactions
A thermally promoted cycloaddition between alkynyliodides and nitrile oxides offers excellent regioselectivity and a broad scope with respect to both starting materials. Further functionalization of the highly decorated iodoisoxazole motifs can be achieved via Suzuki cross-coupling.
see article for more examples